Zhiliang Jia Selected Research

mithramycin A

8/2011	Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.
2/2010	Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity.
7/2008	Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models.
12/2007	Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer.
5/2007	Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A.

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Zhiliang Jia Research Topics

Disease

34	Neoplasms (Cancer) 01/2024 - 01/2006
18	Pancreatic Neoplasms (Pancreatic Cancer) 10/2020 - 05/2007
14	Neoplasm Metastasis (Metastasis) 01/2024 - 01/2006
8	Carcinogenesis 01/2019 - 04/2009
6	Lymphatic Metastasis 07/2013 - 01/2006
5	Stomach Neoplasms (Stomach Cancer) 04/2009 - 01/2006
2	Osteosarcoma (Osteogenic Sarcoma) 01/2024 - 01/2022
2	Hepatocellular Carcinoma (Hepatoma) 01/2016 - 09/2012
2	Colonic Neoplasms (Colon Cancer) 01/2013 - 11/2008
1	Glioblastoma (Glioblastoma Multiforme) 10/2023
1	Cytokine Release Syndrome 01/2022
1	Hematologic Neoplasms (Hematological Malignancy) 01/2022
1	Glioma (Gliomas) 01/2019
1	Hypoxia (Hypoxemia) 12/2017
1	Leukemia 02/2017
1	Adenocarcinoma 08/2014
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 08/2014
1	Pancreatitis 07/2013
1	Intestinal Neoplasms (Intestinal Cancer) 01/2013
1	Neuroendocrine Tumors (Neuroendocrine Tumor) 04/2007
1	Carcinoid Tumor (Carcinoid) 04/2007

Drug/Important Bio-Agent (IBA)

12	Proteins (Proteins, Gene)FDA Link 10/2020 - 01/2006
9	Transcription Factors (Transcription Factor)IBA 12/2017 - 06/2008
6	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 04/2009 - 11/2006
5	mithramycin AIBA 08/2011 - 05/2007
4	Messenger RNA (mRNA)IBA 10/2020 - 11/2008
3	Interleukin-12 (IL 12)IBA 01/2024 - 01/2022
3	RNA (Ribonucleic Acid)IBA 01/2024 - 06/2008
3	CateninsIBA 01/2019 - 08/2014
3	Forkhead Transcription Factors (Forkhead Box Proteins)IBA 05/2014 - 02/2012
3	Small Interfering RNA (siRNA)IBA 01/2013 - 12/2007
3	Bevacizumab (Avastin)FDA Link 07/2008 - 04/2007
3	Sp1 Transcription FactorIBA 07/2008 - 11/2006
2	Chimeric Antigen ReceptorsIBA 01/2024 - 01/2022
2	CytokinesIBA 01/2022 - 07/2013
2	Neurofibromin 2 (Merlin)IBA 11/2015 - 11/2015
2	Forkhead Box Protein M1IBA 02/2015 - 01/2013
2	Calcitriol Receptors (Calcitriol Receptor)IBA 02/2015 - 09/2012
2	Vitamin D FDA LinkGeneric 02/2015 - 09/2012
2	Betulinic AcidIBA 09/2013 - 08/2011
2	Protein Isoforms (Isoforms)IBA 07/2013 - 12/2010
2	Kruppel-Like Factor 4IBA 09/2012 - 06/2008
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 12/2010 - 11/2008
2	Neutralizing AntibodiesIBA 07/2008 - 05/2007
2	ErbB Receptors (EGF Receptor)IBA 12/2007 - 05/2007
1	LigandsIBA 01/2024
1	VimentinIBA 01/2024
1	Transforming Growth Factor beta (TGF-beta)IBA 01/2024
1	Single-Chain AntibodiesIBA 10/2023
1	ChemokinesIBA 10/2023
1	Fibrinogen (Factor I)FDA Link 10/2023
1	Arginine (L-Arginine)FDA Link 10/2020
1	Enhancer of Zeste Homolog 2 ProteinIBA 01/2019
1	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 12/2017
1	3,3'-diindolylmethane (diindolylmethane)IBA 09/2017
1	MethyltransferasesIBA 09/2017
1	Differentiation AntigensIBA 09/2017
1	DNA (Deoxyribonucleic Acid)IBA 09/2017
1	Oncogene Proteins (Oncogene Protein)IBA 02/2017
1	Cadherins (E-Cadherin)IBA 01/2017
1	Tetracycline (Achromycin)FDA LinkGeneric 01/2016
1	TeaIBA 11/2015
1	seocalcitolIBA 02/2015
1	Calcitriol (Calcijex)FDA LinkGeneric 02/2015
1	Lactate Dehydrogenase 5IBA 08/2014
1	EnzymesIBA 05/2014
1	Lamin Type B (Lamin B)IBA 09/2013
1	Complementary DNA (cDNA)IBA 09/2013
1	CeramidesIBA 07/2013
1	SphingolipidsIBA 07/2013
1	Interleukin-6 (Interleukin 6)IBA 07/2013
1	Interleukin-8 (Interleukin 8)IBA 07/2013
1	LipidsIBA 07/2013
1	Chemokine CXCL10IBA 07/2013
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2013
1	Epidermal Growth Factor (EGF)IBA 07/2013
1	Urokinase Plasminogen Activator ReceptorsIBA 01/2013
1	villinIBA 03/2012
1	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 03/2012
1	Caveolin 1IBA 02/2012
1	Gemcitabine FDA Link 08/2011
1	tolfenamic acidIBA 02/2010
1	enhanced green fluorescent proteinIBA 01/2010
1	MethylcholanthreneIBA 01/2010
1	TOR Serine-Threonine KinasesIBA 03/2009
1	Transcription Factor 3IBA 11/2008
1	Platelet-Derived Growth FactorIBA 12/2007
1	Monoclonal AntibodiesIBA 04/2007
1	Oxygen (Dioxygen)IBA 01/2006
1	Endoplasmic Reticulum Chaperone BiPIBA 01/2006
1	Glucose (Dextrose)FDA LinkGeneric 01/2006

Therapy/Procedure

11	Therapeutics 01/2024 - 11/2006
1	Immunotherapy 01/2024
1	Liver Transplantation 01/2016
1	Intraperitoneal Injections 12/2007